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Amebic liver abscess |
| Definition: |
| Amebic liver abscess is a collection of pus in the liver caused by the intestinal parasite Entamoeba histolytica.
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| Alternative Names: |
| Hepatic amebiasis; Extraintestinal amebiasis; Abscess - amebic liver |
| Causes, incidence, and risk factors: |
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Amebic liver abscess is caused by the same organism, Entamoeba histolytica, that causes amebiasis, an intestinal infection. The organism is carried through the blood to the liver where the abscess is formed. Patients may or may not have symptoms of intestinal infection concurrently with liver abscess. The infection is present worldwide, but is most common in tropical areas where crowded living conditions and poor sanitation exist. Africa, Latin America, Southeast Asia, and India have significant health problems associated with this disease. Transmission occurs through ingestion of cysts in fecally contaminated food or water, use of human excrement as fertilizer, and person-to-person contact. Risk factors for amebic liver abscess include malnutrition, old age, pregnancy, steroid use, malignancy, immunosuppression and alcoholism. Recent travel to a tropical region is a risk factor. In the U.S., institutionalized people and male homosexuals are known high risk groups. |
| Symptoms: |
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| Signs and tests: |
These tests detect abscess in the liver:
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| Treatment: |
| Antimicrobial therapy with metronidazole is the usual treatment for liver abscess. The abscess may rarely be drained to help relieve some of the abdominal pain associated with the abscess. Medication such as paromomycin must also be taken to eliminate intestinal amebiasis to prevent recurrence of the disease. |
| Expectations (prognosis): |
| Without treatment, the abscess may rupture and spread into other organs, and death may occur as a result. |
| Complications: |
| The abscess may rupture into the peritoneal (abdominal) cavity, pleural space (lining of the lungs), lungs, or pericardium (sac around the heart). The infection can also spread to the brain. |
| Calling your health care provider: |
| Call your health care provider if symptoms develop after travel to an endemic area. |
| Prevention: |
| When traveling in tropical countries where poor sanitation exists, drink purified water and do not eat uncooked vegetables or unpeeled fruit. Public health measures include improved water purification and waste treatment for underdeveloped countries. |
Reviewed By: Camille Kotton, M.D., Infectious Diseases Division, Massachusetts General Hospital and Brigham and Women's Hospital, Boston, MA. Review provided by VeriMed Healthcare Network.
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