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Nonimmune hemolytic anemia caused by chemical or physical agents
Definition:
Hemolytic anemia or hemolysis of red blood cells (destruction of the red blood cell with release of free hemoglobin into circulation) caused or precipitated by factors other than disease.

Possible chemical or physical causes of hemolysis of red blood cells and hemolytic anemia include:
  • antimalarial agents (quinolone compounds)
  • sulfones
  • sulfonamides (sulfasalazine)
  • nitrofurantoin
  • phenazopyridine
  • Pyridium
  • intravenous water (not half-normal saline or normal saline)
  • arsenic
  • metals (chromium [chromates], platinum salts, nickel compounds, copper, lead, cis-platinum)
  • snake bite (some snake venom contains hemolytic toxins)
Alternative Names:
Hemolytic anemia - nonimmune (caused by chemical or physical agents)

Review Date: 10/5/2001
Reviewed By: Victoria Kennedy, RN, A.D.A.M. editorial.
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