Cranial mononeuropathy VI is a mononeuropathy (damage to a single nerve) involving the sixth cranial (abducens) nerve, one of the cranial nerves that controls eye movement.

Abducens nerve disorders are often associated with diabetic neuropathy, trauma, infections (like meningitis or sinusitis), infarction (tissue damage from loss of blood flow), cranial aneurysms, tumors, or increased intracranial pressure (pressure within the skull). In some cases, no cause can be found.

Because of common pathways through the skull, other cranial nerves (such as the third or fourth cranial nerve) may be affected simultaneously.

Symptoms may include double vision when looking to one side (for unilateral injury). In some cases, there is pain or headaches.

Testing of eye movement shows that one eye has difficulty looking to the side and the other eye moves normally. An eye examination shows the eyes do not align, either at rest or especially when looking in the direction of the weak eye.

A complete medical and neurological examination must be done to determine if other parts of the nervous sytem are affected. Depending on the suspected cause, a patient may undergo blood tests, a head imaging study like an MRI or CT scan and possibly a lumbar puncture (spinal tap).

In some cases, corticosteroids may reduce swelling and relieve pressure on the nerve, while in others the condition may disappear without treatment. Treatment of the cause (if it can be identified) may relieve the symptoms in many cases. Close control of blood sugar levels in diabetics may be beneficial.

Until the nerve heals, an eye patch may alleviate double vision.

Some complications include permanent vision changes.

No specific prevention is available, although patients with diabetes may reduce the risk by controlling their blood sugar.