There are many potential causes of Horner's syndrome. Any interruption of the sympathetic nerve fibers which start in the hypothalamus (a central brain region) and run via the upper spinal cord near the carotid artery and to the face may lead to Horner's syndrome. Such injuries can result from a stroke in the brainstem, injury to the carotid artery, a tumour in the upper lobe of the lung, and cluster headaches.
Rarely, Horner's syndrome may be congenital (present at birth) and associated with a lack of pigmentation of the iris. Eye drops and certain medications may also lead to this condition.
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