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Cancer - vulva |
| Definition: |
| Cancer of the vulva involves tumors that originate at the external structures of the reproductive tract (the labia, the vaginal opening, the urethral opening, and the clitoris).
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| Alternative Names: |
| Cancer - perineum |
| Causes, incidence, and risk factors: |
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Approximately 90% of vulvar cancers are squamous cell carcinoma. About 5% are melanoma, 4% adenocarcinoma, 2% sarcoma, and 1% basal cell carcinoma. The cause has not been identified, but a sexually transmitted disease such as human papilloma virus (HPV - genital warts) may play a role. Vulvar cancer is relatively rare, accounting for about 5% of all gynecological cancers and less than 1% of all new cancers in women. Cancer of the vulva usually occurs in postmenopausal women with peak incidence between 65 and 75 years of age. However, 15% of the cases occur in women 40 years or younger. Risk factors include previous HPV infection, previous cervical cancer or vaginal cancer, syphilis infection, diabetes, obesity, and hypertension. Early lesions of the vulva that may change into vulvar cancer are called vulvar intraepithelial neoplasia. |
| Symptoms: |
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| Signs and tests: |
| A routine pelvic examination may be the best means of noting early changes. Skin changes include any color changes and the presence of lesions that may vary in size and shape. Excision and biopsy of the lesion is critical for accurate diagnosis. |
| Treatment: |
| Surgical removal is the standard treatment. If the tumor is large (more than 2 cm) or has grown deeply into the underlying skin, excision of the lymph nodes in the groin may be necessary as well. Radiation, with or without chemotherapy, may be used to treat advanced tumors or tumor recurrences. |
| Support Groups: |
| The stress of illness can often be helped by joining a support group where members share common experiences and problems. See cancer - support group. |
| Expectations (prognosis): |
| Five-year survival rates in women who are diagnosed and treated in the early stages of vulvar cancer can be excellent (more than 90%). The outcome depends on the size of the lesion, the type of cancer, and whether or not spreading (metastases) to the lymph nodes of the region has occurred. Recurrence at or near the original site is fairly common. |
| Complications: |
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Metastasis (spread to other organs) Complications of radiation, surgery, or chemotherapy |
| Calling your health care provider: |
| Call your health care provider if any vulvar lesion, color changes, or local irritation persists longer than 2 weeks. |
| Prevention: |
| Safer sex behaviors and reducing or controlling the risk factors may decrease the risk in some women. |
Reviewed By: Kevin Knopf, M.D., M.P.H., Hematologist/Oncologist and Director of Clinical Research, Annapolis Oncology/Hematology Center, Annapolis, MD. Review provided by VeriMed Healthcare Network.
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