Unless there are other associated defects, there are usually no complications associated with PFO. There have been some studies suggesting that older patients with PFOs have a higher rate of a certain type of stroke (thromboembolic). The reason for this is that older people frequently develop blood clots in the veins in their legs. These clots can sometimes travel from their original site to the right side of their heart.
If PFO is present, the clot can then pass from the right side to the left side from whence it can travel to the brain and become lodged there, preventing blood flow to that part of the brain (stroke).
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