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| Definition: |
A quantitative test that measure the amount of mucopolysaccharides excreted in the urine over a 24-hour period.
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| Alternative Names: |
AMP; Dermatan sulfate - urine; Urine heparan sulfate; Urine dermatan sulfate; Heparan sulfate - urine
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| How the test is performed: |
A 24-hour urine sample is needed.
The health care provider will instruct you, if necessary, to discontinue drugs that may interfere with the test.
- On day 1, urinate into the toilet upon arising in the morning.
- Collect all subsequent urine (in a special container) for the next 24-hours.
- On day 2, urinate into the container in the morning upon arising.
- Cap the container. Keep it in the refrigerator or a cool place during the collection period. Label the container with your name, the date, the time of completion, and return it as instructed. Deliver it to the laboratory or your health care provider as soon as possible upon completion.
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| How to prepare for the test: |
| No special preparation is needed. Drink a normal volume of fluids, and consume a normal diet. |
| How the test will feel: |
| The test involves only normal urination, and there is no discomfort. |
| Why the test is performed: |
| This test is performed to detect a rare disorder of excess acid mucopolysaccharides accumulation (especially dermatan sulfate and heparan sulfate) in the tissues. The severe form of this disorder can lead to Hurler's syndrome. Typically this test is only ordered for infants where there is a family history of mucopolysaccharidosis. |
| Normal Values: |
| Normal acid mucopolysaccharide values vary with age, and the normal range of values vary between laboratories. The laboratory performing the test should be consulted for interpretation of the test result. |
| What abnormal results mean: |
| Abnormally high levels of acid mucopolysaccharides reliably indicates mucopolysaccharidosis, and further detailed studies can identify the enzyme which is defective. |
| What the risks are: |
| There are no risks (except for the chance of inaccurate results if all of the urine is not collected during the 24-hour period). |
| Special considerations: |
| If the test was performed on an infant, remove all remaining adhesive from the collection device with warm soap and water. |
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Review Date: 11/26/2001
Reviewed By: Michael C. Milone, M.D., Ph.D., Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
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