Abnormal results indicate that coccidioides antibodies are present. This can indicate a current or prior infection. The test may be repeated after several weeks to detect a rise in titer, which helps to confirm an active infection. Titers greater than 1:16 usually indicate active infection (i.e., 1:32 or higher).
In general, the worse the infection, the higher the titer, except in patients with weakened immune systems.
There can be false positive tests in patients with the fungal disease histoplasmosis, and false negative tests in patients with only solitary lung masses from coccidioidomycosis.
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