DHEA-sulfate

Definition:
This blood test measures the amount of DHEA-sulfate in the blood.

Alternative Names:
Dehydroepiandrosterone sulfate

How the test is performed:
Adult or child:
Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic, and a tourniquet (an elastic band) or blood pressure cuff is placed around the upper arm to apply pressure and restrict blood flow through the vein. This causes veins below the tourniquet to distend (fill with blood). A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the tourniquet is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.

Infant or young child:
The area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. Cotton or a bandage may be applied to the puncture site if there is any continued bleeding.
How to prepare for the test:
Adult:
No special preparation is necessary.

Infants and children:
The physical and psychological preparation you can provide for this or any test or procedure depends on your child's age, interests, previous experiences, and level of trust. For specific information regarding how you can prepare your child, see the following topics as they correspond to your child's age:
How the test will feel:
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performed:

This test is used to evaluate the function of the adrenal glands. DHEA-sulfate is a weak androgen (male hormone) that is produced by the adrenal cortex in both men and women. The adrenal gland in one of the major sources of androgens in women (the other being the ovaries which produce testosterone).

DHEA-S is measured in women exhibiting symptoms of virilism (male body characteristics) or hirsutism (excessive hair growth). It is also in children with precocious puberty.

Normal Values:

Normal values for serum DHEA sulfate are as follows:

  • Men: 800-5600 mcg/l
  • Women: 350-4300 mcg/l

Normal values vary with sex and age.

Note: mcg/dl = microgram per deciliter

What abnormal results mean:

DHEA-S increased:

  • Congenital adrenal hyperplasia
  • Adrenal carcinoma
  • Virilizing tumors of the adrenals
What the risks are:
  • Excessive bleeding
  • Fainting or feeling light-headed
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)
  • Multiple punctures to locate veins
Special considerations:
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Review Date: 2/23/2002
Reviewed By: Mary D. Ruppe, M.D., Division of Endocrinology and Metabolism, Johns Hopkins Hospital, Baltimore, MD. Review provided by VeriMed Healthcare Network
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