The objective of treatment is to decompress the bowel and pass an intestinal tube to prevent swallowed air from further distending the bowel. If decompression is not achieved or the patient does not improve, often within 24 hours, a colectomy (surgical resection of a portion or all of the colon) is indicated.
Fluid and electrolyte replacement help to prevent dehydration and shock.
Use of corticosteroids may be indicated to suppress the inflammatory reaction in the colon if the megacolon has resulted from active inflammatory bowel disease. Antibiotics may be given to prevent sepsis (a severe infection).
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