Causes of testicular failure include chromosomal abnormalities, testicular torsion, direct trauma to the testicles, diseases that affect the testicle (such as mumpsorchitis and testicular cancer), and a variety of drugs. The condition is uncommon.
Increased risk is associated with activities that may cause constant, low level trauma to the scrotum (such as riding a motorcycle) or frequent administration of a drug known to affect testicular function (such as heavy marijuana use or taking some prescription medications). Men who had undescended testicles at birth are at higher risk.
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