Expectant mothers who are infected with syphilis can transmit the disease through the placenta to their unborn infants. Congenital syphilis is a severe, disabling, and often life-threatening condition for the infant. Nearly half of all children infected with syphilis during gestation die shortly before or after birth.

Infants who survive develop early-stage and late-stage symptoms of syphilis if not treated. Early-stage symptoms include irritability, failure to thrive, and nonspecific fever. Some infants develop a rash and lesions (sores) on the borders of the mouth, anus, and genitalia (called condyloma lata).

Some of these lesions may resemble the wart-like lesions of adult syphilis. A small percentage of infants have a watery nasal discharge (sniffles) and a saddle nose deformity resulting from infection in the cartilage of the nose. Bone lesions are common, especially in the upper arm (humerus).

Later signs appear as tooth abnormalities (Hutchinson teeth), bone changes (saber shins), neurological involvement, blindness, and deafness. Despite the fact that this disease can be cured with antibiotics if caught early, rising rates of syphilis amongst pregnant women in United States have recently increased the number of infants born with congenital syphilis.

• Irritability
• Failure to gain weight or failure to thrive
• Watery discharge from the nose
• Early rash
  • Small blisters (vesicles) on the palms and soles
• Later rash
  • Copper-colored, flat or bumpy (maculopapular) rash on the face, palms, soles
• Rash at the junction of the skin and mucus membranes of the mouth, genitalia, and anus
• No bridge to nose (saddle nose)

• Bone pain
• Refusal to move a painful extremity
• Saber shins (bone abnormality of the lower leg)
• Joint swelling (joint effusion)
• Abnormal teeth (notched and peg shaped -- called Hutchinson teeth)
• Scarring of the skin around earlier lesions on the mouth, genitalia, and anus (called rhagades)
• Visual loss
• Clouding of the cornea
• Decreased hearing or deafness
• Gray, mucous-like patches on the anus and outer vagina (condyloma lata)

The physical examination may show signs of bone inflammation (periosteal elevations or osteochondritis). There may be evidence of hepatomegaly (enlarged liver) and splenomegaly (enlarged spleen).

Tests on the mother may include:

• VDRL
• FTA-ABS fluorescent treponemal antibody test

If the disorder is suspected at the time of birth, the placenta will be examined for signs of syphilis.

• On an older infant or child may include:
  
  • Serologic test for syphilis (VDRL and FTA-ABS)
  • Lumbar puncture to look for evidence of syphilis in the brain and central nervous system
  • Microscopy, dark field examination (demonstrates Treponema pallidum)
  • X-ray of the bone(s)

• Blindness
• Deafness
• Facial deformity
• Neurological abnormalities

Safer sexual practices can help prevent infection with syphilis. If you suspect you have a sexually-transmitted disease like syphilis, seek medical attention immediately to avoid complications like infecting a fetus during pregnancy or birth.

Prenatal care for expectant mothers is critical. During prenatal care evaluations, a routine serologic test for syphilis is done. This identifies infected mothers and allows them to be treated to minimize the risks to the infant and to themselves.