Reye's syndrome is most often seen in children from 4 to 12 years old, with a peak incidence at age 6. It is often associated with children who are given aspirin-containing medicines while they have either chickenpox (varicella) or the flu (influenza).
The illness has a rapid onset and symptoms may vary greatly. Changes in mental status occur including delirium, combative behavior, and coma.
Typically, Reye's syndrome follows an upper respiratory infection or chickenpox by about a week. It frequently begins with vomiting, which is persistent over many hours.
The vomiting is rapidly followed by irritable and combative behavior. As the condition progresses, the child may become semi-conscious or stuporous. Ultimately, seizures and coma develop, which can quickly lead to death.
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