Early symptoms are often systemic and may include fatigue, malaise (an ill feeling), fever, and a sense of discomfort around the nose and sinuses. Upper respiratory infections such as sinusitis or ear infections frequently precede the diagnosis of Wegener's Granulomatosis. Other upper respiratory symptoms include nose bleeds, pain, and ulcers or sores around the opening of the nose.
Persistent fever without an obvious cause (fever of undetermined origin -- FUO) may be an initial symptom. Night sweats may accompany the fever. Anorexia and weight loss are common. Skin lesions are common, but there is no one characteristic lesion associated with the disease.
Kidney disease is necessary to make the definitive diagnosis of Wegener's Granulomatosis. The urine may be bloody, which often first appears as red or smoky urine. It may have no symptoms, however, it is readily diagnosed with laboratory studies. Eye problems develop in a significant number of patients and may range from a mild conjunctivitis to severe inflammation of the eyeball and the tissues around the eyeball. Additional symptoms include:
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