Superior vena cava (SVC) obstruction is a relatively rare condition. Most often it is caused by variety of cancers that can be found in the mediastinum (the area of the chest under the breastbone and between the lungs).

These can include lymphomas, cancer of the lung with extension into the mediastinum, breast cancer, testicular cancer, thyroid cancer, and thymic tumors. Superior vena cava syndrome can also be caused by non cancerous conditions that cause chronic fibrosis (scarring).

These can include lung infections, such as tuberculosis, histoplasmosis infection, and thrombophlebitis (particularly extension of thrombophlebitis of superficial veins or the subclavian vein). Other causes of superior vena cava obstruction include aortic aneurysm, constrictive pericarditis, and goiters.

• neck swelling, facial swelling, or arm swelling
• swelling around the eye socket (periorbital)
• reddish face or cheeks
• reddish palms
• reddish mucous membranes (inside the nose, mouth, and so on)
• redness changing to blueness later
• headache
• dizziness
• vision changes
• fainting
• decreased alertness

An examination may show dilated cutaneous (skin) veins of the face, neck, and upper chest. Blood pressure is often high in the arms and low in the legs.

A bronchoscopy may be performed if lung cancer is suspected.

Obstruction of the SVC may show on:

• chest X-ray
• MRI of chest or CT scan of the chest
• coronary angiography
• Doppler ultrasound
• radionuclide ventriculography

This disease may also alter the results of the following tests:

• liver scan
• abdominal MRI

The goal of treatment is relief of the obstruction.

Diuretics may be used to relieve swelling.

The cause must be identified and treated. This may include radiation, chemotherapy, surgical removal of tumors, or other treatment. Surgery to bypass of the obstruction is rarely performed.